Mental health research studies in Ontario

The goal of this study is to determine the feasibility of using a psychosocial intervention culturally adapted in China…

This study is a long-term extension (LTE) of the parent Study ORX750 0201, and will provide long-term open-label…

This is a Phase 3, multicenter, randomized, double-blind, parallel-group, placebo-controlled clinical study to assess…

The goal of this neuroimaging clinical trial is to test whether psilocybin produces significant immediate changes in…

Narcolepsy Type 1 (NT1), Narcolepsy Type 2 (NT2), and Idiopathic Hypersomnia (IH) are rare conditions that make people…

This is a Phase 3, randomized, double-blind, placebo-controlled, multicenter, global clinical study to assess the…

This Phase 2 study (protocol number VLS-01-203) will determine the efficacy, safety, and tolerability of short-term…

The purpose of this study is to measure decreases in daytime sleepiness, cataplexy (sudden loss of muscle tone), and…

The purpose of this study is to measure decreases in daytime sleepiness, and disease symptoms in participants with…

The primary purpose of this study is to evaluate the optimal doses of E2086 compared to placebo in participants with…

The purpose of this study is to measure decreases in daytime sleepiness, cataplexy (sudden loss of muscle tone), and…

The primary objective of this study is to evaluate the efficacy of NBI-1065845 compared with placebo as an adjunctive…

The goal of this observational study is to investigate the accuracy of the device in characterizing perimenopausal and…

The goal of this clinical trial is to examine whether a 5-day course of bilateral accelerated deep transcranial…

The goal of this clinical trial is to test whether an accelerated deep Transcranial Magnetic Stimulation (dTMS)…

The purpose of this trial is to compare the treatment efficacy (improvement in depressive symptoms) of accelerated TBS…

The goal of this feasibility study is to determine the tolerability and safety of add on treatment with L-methylfolate…

This study evaluates the impact of conjugated estrogens/ bazedoxifene (CE/ BZA) on the mood (depression and anxiety) in…

Epidemiological studies suggest that the use of cannabis is associated with an increase in the risk of motor vehicle…

Mood disorders such as depression and bipolar disorder affect over 350 million people around the world. While several…

The goal of this clinical trial is to learn about how psychotherapy works for children and adolescents aged 8 - 15 with…

Schizophrenia and depression are among the most disabling disorders in all of medicine. Cognitive deficits play a key…

This trial aims to obtain initial evidence about the clinical efficacy and modulation of neurophysiological markers in…

Bipolar disorder (BD) is a frequent and lifelong recurrent mood disorder with treatment-resistant depressive episodes.…

Pregnant and postpartum individuals often have difficulty sleeping and these sleep problems can negatively impact both…

The goal of this clinical trial is to evaluate if the combined treatment with EXOMIND (BTL-699-2) and EMSELLA…

Bipolar disorder (BD) is a lifelong condition characterized by recurrent episodes of depression and (hypo)mania.…

The purpose of this study is to better understand how certain brain systems work in people with depression, especially…

The goal of this clinical trial is to learn if administering a high dose stimulant with Contingency Management reduces…

The purpose of this study is to assess the efficacy of the oral medication IGC-AD1, a THC-based…

Forensic patients often display cognitive deficits, particularly in the domain of executive functions, that represent a…

Depression is a leading cause of disability worldwide, affecting up to 300 million people globally. Despite its high…

Repetitive transcranial magnetic stimulation (rTMS) is a Health Canada approved treatment for major depression. Theta…

In this triple-blind randomized controlled trial, we ask if targeting intermittent theta burst stimulation (iTBS) based…

Repetitive transcranial magnetic stimulation (rTMS) is a Health Canada approved treatment for major depression. Theta…

Problems with substance use are common in prisoners. Since most substances are still illegal in Canada, substance use…

Treatment refractory PTSD is a chronic and debilitating psychiatric disorder associated with high morbidity. Despite…

In this study, the investigators will be examining the effects of the deep repetitive transcranial magnetic stimulation…

This study will look at how a new medication (dextromethorphan and bupropion taken together in one pill) affects the…

Dialectical behavior therapy (DBT) will be conducted over 1 year in youth with and/or at familial risk for bipolar…

The goal of this observational study is to learn about remote mental health monitoring technology for adults with…

In Canada, 35,000 people are experiencing homelessness on any night. Compared to the general population, people…

The purpose of this study is to establish how personalization of repetitive transcranial magnetic stimulation (rTMS)…

This is a quasi-experimental, multi-site cluster controlled clinical trial design with two intervention arms--Treatment…

The COVID-19 pandemic has resulted in increased workload and concerns about personal and family safety for frontline…

This study is being conducted to assess the effects of the Feel Free® Classic Tonic on stress in healthy adults. The…

The goal of this clinical trial is to determine if attenuations in cardiac output drive the blunted blood pressure…

The current proposal is aimed to confirm the efficacy of this novel therapeutic method (autonomous eye movement…

Emotion Focused Family Therapy (EFFT) is a promising intervention that aims to teach parents advanced skills to support…

Obstructive sleep apnea (OSA), which causes abnormal pauses in breathing during sleep, is common in patients with…

This human laboratory study aims to assess the effects of cannabidiol on alcohol consumption and craving in…

The primary objective of this randomized study is to evaluate the effect of a virtual reality (VR) video on…

Psilocybin, the chemical component of "magic mushrooms", has been administered with psychological support in several…

The prevalence of major depressive disorder (MDD) is \~5.0%, and rates of co-occurring SUDs in these patients approach…

Dialectical behavior therapy (DBT) is a comprehensive, third-wave psychological intervention designed for patients with…

The goal of this study is to collect feasibility data on combining structured exercise aimed to improve physical…

The goal of this clinical trial is to evaluate the safety and initial effectiveness of Magnetic Resonance-guided…

Substance use disorder (SUD) or addiction to drugs/alcohol is a devastating disease. Over 40,000 overdose deaths have…

Children with medical complexity (CMC) often have trouble breathing at night and need to use a breathing machine. This…

The goal of this clinical trial is to learn if CBT(Cognitive Behavioural Therapy)-MyOWL(Optimizing Wellness through…

Approximately four thousand Canadians die by suicide every year, and suicide is the second leading cause of death in…

Psilocybin, the chemical component of "magic mushrooms", has been administered with psychotherapy in several randomized…

A prospective longitudinal cohort study that will assess the effect of a Personalized Medicine (PM) clinic…

Repetitive transcranial magnetic stimulation (rTMS) is an alternative non-invasive treatment to help people quit…

Heart failure is a high-risk, chronic condition that impacts patients' mental health. Approximately 50% of heart…

The investigators have developed a novel suicide intervention, Integrated Suicide and Trauma Therapy (ISTT). ISTT…

This is a study that will recruit patients from the neurosurgery clinic and the regular TMS clinic. It's a smaller…

The goal of this clinical trial is to design an online Cognitive Behavioural Therapy (CBT) and Acceptance Commitment…

Depression is a common condition, with serious negative effects on the health and quality of life of those affected.…

Insomnia is defined as the inability to fall asleep or stay asleep at night and it is one of the most prevalent sleep…

The goal of this observational study is to learn about the comparative acute effects of ketamine vs esketamine in…

Indigenous youth in Northwestern Ontario who need mental health supports experience longer waits than non-Indigenous…

Indigenous youth in Northwestern Ontario who need mental health supports experience longer waits than non-Indigenous…

New challenges, stressors, and a loss of support often accompany the transition from adolescence to adulthood. Not…

Youth in Canada are in need of novel, innovative approaches to support their mental health and wellbeing. Within this…

The goal of this clinical trial is to learn if intravenous (IV) ketamine with Dialectical Behavioural Therapy (DBT)…

The aim of this study is to test the hypothesis that low-frequency rTMS (LFR) works as well as the established…

The goal of this clinical trial is to learn if Lemborexant works to treat residual insomnia in adults with depression…

Low intensity focused ultrasound (LIFUS) has the potential to be used as a means of non-invasive neuro-modulation. To…

This study will evaluate the long-term safety and tolerability of NBI-1065845 as an adjunctive treatment in…

The purpose of this trial is to conduct an adequately powered clinical trial of once daily LFR for individuals…

The goal of this clinical trial is to evaluate the safety and initial clinical effectiveness of MRI-guided focused…

The goal of this clinical trial is to evaluate the safety and initial effectiveness of MR-guided focused ultrasound…

This Phase 3 clinical trial is designed to evaluate the efficacy and safety of maridebart cafraglutide compared to…

This Phase 3 clinical trial is designed to evaluate the efficacy and safety of maridebart cafraglutide compared to…

This study aims to evaluate the safety, feasibility, acceptability, and effectiveness of MDMA-assisted…

The goal of this clinical trial is to investigate the impact of a technology-based meditation program in the inpatient…

Obesity is a common chronic disease linked with increased risk for other illnesses and earlier death. Our team and…

This study is being done to examine the feasibility, including recruitment, retention and acceptability of a randomized…

Post-traumatic stress disorder (PTSD) is a debilitating and highly prevalent psychiatric disorder that develops in the…

People with bipolar disorder (BD) are at high risk of relapse following hospital discharge, partly due to a lack of…

Behavioural and psychological symptoms of dementia (BPSD), such as depression affect up to 90% patients with dementia.…

The study will evaluate the efficacy of NBI-1065845 compared with placebo as an adjunctive treatment in participants…

This study is an open-label, single-arm, proof-of-concept study, wherein treatment resistant bipolar depression (TRBD)…

The goal of this randomized controlled clinical trial is to assess a novel cognitive-behavioral program for sleep and…

This is a study that will test a predictive biomarker algorithm based on results from a previous study. The goal of…

The goal of this clinical trial is to compare the effectiveness of the Breaking the Cycle (BTC) and Maxxine Wright (MW)…

Standard Behavioral Parent Training (BPT) is often less effective for parents experiencing depression. As such, the…

The goal of this study is to determine whether a randomized controlled trial using oropharyngeal exercises to treat…

This randomized clinical trial will compare three groups of individuals with cervical/thoracic, complete or incomplete…

Perinatal depression and anxiety (PDA) are the leading causes of maternal mortality in developed countries. Women with…

The study investigators are interested in learning more about how drugs, that are given to children by their health…

This 2-arm study will recruit participants with 1) alcohol use disorder and 2) cannabis use disorder for a 12-week…

This is a pilot study examining the delivery of a remotely delivered, one-on-one, individualized physical activity (PA)…

The study intervention is DBT adapted for youth with and/or at familial risk for bipolar disorder. Participants will…

Major depressive disorder (MDD) is a common condition involving recurring periods of depression. One of the major…

The goal of this observational study focuses on understanding and addressing a subset of persistent neuropsychiatric…

The goal of this multi-centre phase I/II open-label, single-arm study is to determine the safety, feasibility,…

We propose a first-of-its-kind open-label clinical trial to investigate the feasibility, tolerability, and safety of…

This is an open-label trial evaluating feasibility, tolerability, safety and efficacy of psilocybin assisted cognitive…

The purpose of this study is to see if one or two doses of psilocybin is more effective in relieving depressive…

Postpartum anxiety (PPA) affects up to 20% of mothers in the first year after delivery, with mothers often reporting…

This clinical trial will examine the efficacy of continuous positive airway pressure (CPAP) therapy in improving…

This study aims to explore how repetitive transcranial magnetic stimulation (rTMS), a treatment for depression, affects…

This is a randomized, sham-controlled trial to determine whether treatment with transcranial direct current stimulation…

This prospective observational study aims to describe the effectiveness of MC on pain, epilepsy, sleep and /or…

Patients with chronic pain are often prescribed long-term opioid therapy, despite the serious risks and growing…

This study will investigate pregnancy, neonatal, and infant outcomes in women exposed to QUVIVIQ during pregnancy…

There has been a considerable rise in cannabis consumption in recent years, with estimates of 200 million individual…

The RESPOND trial explores the link between early life adversity and later life depressive symptoms. The investigators…

The current clinical trial is focused on evaluating the efficacy of rTMS for treatment of depression in youth and young…

Youth aged 15-24 are likelier to have depression than all age groups in Canada. One-third of depressed youth do not…

This study evaluates the safety, feasibility, and preliminary efficacy of focused ultrasound (FUS) neuromodulation…

The goal of this clinical trial is to evaluate the safety, feasibility, and preliminary clinical benefit of focused…

This Phase 2a clinical trial is designed to evaluate the safety, tolerability, and preliminary efficacy of a 3 mg dose…

Uncontrolled hypertension is associated with an increased risk of heart disease, stroke, and mortality. Obstructive…

To assess the feasibility of conducting a randomized controlled trial (RCT) to determine the effectiveness of…

This study will investigate whether a movement and body-based treatment can benefit adults with Post-traumatic Stress…

There are currently no approved medications for the treatment of anxiety in children and youth with neurodevelopmental…

Tobacco use is a risk factor for at least 20 types of cancer and remains the leading preventable cause of cancer in…

SUSTAIN (Studying Solriamfetol Modulation of TAAR-1, Dopamine, and Norepinephrine in Shift Work Disorder) is a Phase 3,…

Bipolar disorders (BD) are a group of complex disorders that impact mood, behaviour and cognition and are known to…

The goal of this clinical trial is to determine if active transcranial direct current stimulation (tDCS) plus…

Major Depressive Disorder (MDD) has a high prevalence, is the leading cause of disability, and currently available…

Major Depressive Disorder (MDD) is a very common illness that is usually treated with antidepressant medication.…

The INITIATE Study is a randomized controlled trial that is testing an intervention designed to increase long-term…

Depression, anxiety, and related disorders such as post-traumatic stress and obsessive compulsive disorder affect about…

The high frequency of unplanned hospital visits of patients with chronic hypercapnic respiratory failure (e.g., chronic…

The Sunnybrook Type 2 Diabetes Study (S2DS) is a prospective observational study of people with prediabetes or Type 2…

The purpose of this trial is to determine if intermittent theta-burst stimulation (iTBS) can reduce the symptoms of…

The goal of this clinical trial is to explore the effects of non-invasive brain stimulation protocols using…

This study seeks to bridge the knowledge-to-action gap regarding psychosocial treatment "dosing" for youth with and/or…

The purpose of this study is to test the impact of Healing Circuits™; a structured mental health support model on IBD…

Tobacco smoking is the leading preventable cause of morbidity and mortality worldwide. However, currently available…

Psychological and existential distress are a common cause of suffering among patients nearing the end of life, and a…

Spinal cord injury (SCI) has been shown to be associated with impairment to the autonomic nervous system in the form of…

This study aims to investigate the feasibility and effectiveness of a cognitive behavioral coping skills program,…

Psilocybin, the chemical component of "magic mushrooms", has been administered with psychotherapy in several randomized…

This is a feasibility study for trigeminal nerve stimulation (TNS) in patients with treatment-resistant generalized…

The goal of this clinical trial is to treat active suicidal ideation in individuals with Major Depressive Disorder…

Restless Legs Syndrome (RLS) is a disorder that causes painful and uncomfortable sensations in the legs, and its…

The goal of this observational study is to validate the Creyos online cognitive assessment platform in individuals with…

Obstructive sleep apnea (OSA), which occurs in 1-4% of children, is a serious condition where a person stops breathing…